Mae Sot is visited by tourists, especially those crossing the border to Myanmar, going north to Mae Hong Son Province, or those traveling further south to attractions in Amphoe Umphang. The few streets in the downtown core are lined with gem shops. Rim Moei Market, locate just the base of Thai side of Thai-Myanmar Friendship Bridge, is the most famous market of the area offering imported goods. Two Mussur Markets (old and new one) located on AH1 near the border between Mae Sot and Amphoe Mueang Tak is the market for agriculture products.

Wat Phra Boromthat & Ancient Tak City This monastery, located 25 kilometres upstream, in Amphoe Ban Tak, in an area which used to be the former site of Tak city. There are several ruins in the area, including a hilltop pagoda which was constructed, according to legend, by king Ramkhamhaeng of Sukhothai (reign 1275-1317) to commemorate his victory in single combat on elephant back against King Khun Sam Chon, the ruler of Muang Shot (currently Amphoe Mae Sot).

Situated in Mae Sot Municipality, the temple was built approximately 200 years ago. Several restorations have been made, including the construction of the new chedi in the same architectural style as that of the Chawedagong in Myanmar. Attractions within the temple include a Buddha image in the Maravichai style and a 200 year old drum.

Highway 105 heads westwards through mountainous jungle, past Lan Sang National Park with its beautiful waterfalls and villages of the Meo, Lisu and Lahu tribes, to Mae Sot, the border town for Myanmar (98 km (61 mi.)). Higher slopes and mountain watersheds are covered with hill evergreen and hill pine forest. The main forest types in the lower areas are mixed deciduous, dry evergreen and dipterocarp forest. The variety of forest habitats provides homes for a rich diversity of wildlife such as barking deer, sambar deer, wild pig, monkey, languar, flying lizard and the rare serow (a mountain goat) and golden cat. Lan Sang is also a historical park, as King Taksin once rested his army in this area during their long march to Chiang Mai.

Pha Charoen waterfall national park covers areas in Mae Sot and Phop Phra districts of Tak province in north-western Thailand. Pha Charoen waterfall also called "97-step Rom Klao" is located close to the headquarters and highway 1090. The 50 meters high waterfall consists of 97 ladder-shape steps or tiers. Pa Wai waterfall having 100 levels is a limestone fall flowing down from Wai forest. It is located near Tak - Kamphaeng Phet border, 20 km north of highway 1090. At the kilometer marker 40, take a turn-off road to Pa Wai village (17km) and continue further 3 km to the waterfall. The fall is open to visitors in winter and dry season.

Overlooking Maenam Moei and Myanmar is Wat Phra That Doi Din Kiu, a hill-top forest temple, just 11 kilometers northwest of Mae Sot. The chedi is special as it is constructed in the same style as Kyaiktiyo Pagoda in Myanmar. In addition, the chedi was built on a rock which seems to have been balanced on the edge of a cliff.

Situated on the bank of Maenam Moei, Talad Rim Moei is a place where local products and precious stones such as jade and garnet from Myanmar are available. Tourists interested in visiting Myawadi in Myanmar (just across Maenam Moei) can take boats from this market.

Thai-Myanmar Friedship Bridge which connects the Asian Highway between Thailand and Myanmar, is located at Tambon Tha Sai Luad, opposite a town called Myawadi in Myanmar. The Asian Highway also runs to other regions in South Asia, the Middle East and Europe. The bridge opens daily from 8.30 a.m. until 4.30 p.m. Border passes for a fee of 20 baht for Thais and 10 baht for people from Myanmar can be obtained from either Mae Moei City or Mae Sot Municipal.

Namtok Thi Lo Su is located in the Umphang Wildlife Sanctuary, a UNESCO World Heritage site, which links with the Thung Yai Naresuan and Huay Kha Kaeng Reserves, as well as Khlong Lan and Mae Wong National Parks. Together, they form Thailand's largest wildlife haven and Southeast Asia's top virgin forest. Thi Lo in the local language means waterfall and Su means loud. Thus, Thi Lo Su means waterfall that makes a loud noise. This is due to its size and the intense flow of the stream. In Karen, "Thi Lo Su" means Black Waterfall. The biggest and the most beautiful waterfall in Thailand, Namtok Thi Lo Su is also considered the sixth biggest waterfall in the world.

Khuean Bhumibol - Located approximately 60 kilometers north of Tak city in Amphoe Sam Ngao is Bhumibol Dam, Thailand's largest dam. Formerlly known as Yanhi Dam, this is Thailands first all-purpose dam, built from concrete designed as a huge curve cutting across Maenam Ping between Khao Kaew and Khao Yanhi. The dam produces most of Thailand's hydro-electric power and ranks 8th in the world of hydro-electricity producing dams. The Dam is operated by the Electricity Generating Authority of Thailand, which also provides on-site accommodations.